Effect of lactoferrin on pregnant women with iron deficiency anemia
Oral administration of lf100mg / time before meal twice a day can significantly increase the concentration of total serum iron and hemoglobin compared with oral ferrous sulfate, and has nothing to do with gestational age, without side effects.
In a further clinical trial of 143 pregnant women with ID or IDA, we found that compared with oral ferrous sulfate, oral lf can significantly increase the number of red blood cells and serum ferritin. In order to obtain the effect of oral lf on the iron homeostasis of the system, we carried out experiments on 5 pregnant women with ID and IDA. The subjects took lf for 30 days, and then took ferrous sulfate for 30 days. The red blood cell count, hemoglobin, total iron level, ferritin and IL-6 concentration in serum were measured.
All blood indexes increased after lf treatment, and all indexes decreased after oral administration of ferrous sulfate for 30 days. On the contrary, IL-6 decreased significantly after lf treatment, and the detection value of oral ferrous sulfate increased again. In accordance with this, 120 mg / day of oral iron can cause inflammation in healthy volunteers. The concentration of IL-6 in serum increases while the total serum iron and serum ferritin decrease by 3. On the contrary, the level of IL-6 decreased and the concentration of total serum iron and serum ferritin increased after lf treatment.
In conclusion, the above clinical trials have proved that oral lf can prevent and treat ID and IDA in pregnant women. We believe that LF can recover the hematological indexes and reduce the adverse effects of ID and IDA on pregnancy by reducing the level of pro-inflammatory cytokines in pregnant women.